CPC A61N 1/327 (2013.01) [A61N 1/025 (2013.01); A61N 2/002 (2013.01); A61N 2/02 (2013.01)] | 10 Claims |
1. A method for treating a subject in need thereof, the method comprising:
selecting a treatment region within a central nervous system (CNS);
mounting, on an external surface of the subject, an electric field source that comprises one or both of (i) a plurality of electrodes and (ii) a magnetic field source configured to generate a changing magnetic field; and
applying a pulsed electric field with said electric field source to at least a portion of the CNS,
wherein the pulsed electric field has an electric field strength of less than 148 V/cm and a frequency of less than 75 Hz within the treatment region, being below a threshold for inducing electroporation in the treatment region,
wherein applying the pulsed electric field induces disruptive permeability of a blood brain barrier or a blood cerebrospinal fluid barrier in the treatment region.
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