US 11,931,481 B2
Microporous annealed particle gel system
Dino Di Carlo, Los Angeles, CA (US); Westbrook Weaver, San Diego, CA (US); Tatiana Segura, Durham, NC (US); Jaekyung Koh, Los Angeles, CA (US); Philip Scumpia, Los Angeles, CA (US); and Donald R. Griffin, Charlottesville, VA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed on Jul. 30, 2022, as Appl. No. 17/877,933.
Application 17/877,933 is a division of application No. 16/077,985, previously published as PCT/US2017/017837, filed on Feb. 14, 2017.
Claims priority of provisional application 62/295,933, filed on Feb. 16, 2016.
Prior Publication US 2022/0370686 A1, Nov. 24, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/52 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 39/39 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); C08H 1/00 (2006.01); A61K 39/00 (2006.01)
CPC A61L 27/52 (2013.01) [A61K 9/0019 (2013.01); A61K 9/1635 (2013.01); A61K 9/1641 (2013.01); A61K 9/1652 (2013.01); A61K 39/39 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); C08H 1/00 (2013.01); A61K 2039/60 (2013.01); A61K 2039/6093 (2013.01); A61L 2300/426 (2013.01); A61L 2300/64 (2013.01); A61L 2400/06 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A system, comprising:
(a) a plurality of microgel particles, wherein at least one microgel particle of the plurality of microgel particles comprises a hydrogel backbone and one or more annealing components; and
(b) an annealing agent configured to couple the one or more annealing components of two or more microgel particles of the plurality of microgel particles to form a covalently-stabilized scaffold of microgel particles having pores formed between the microgel particles, wherein the pores are on the 10 micrometer scale and are substantially devoid of hydrogel.