US 11,931,480 B2
Microporous annealed particle gels and methods of use
Dino Di Carlo, Los Angeles, CA (US); Westbrook Weaver, San Diego, CA (US); Tatiana Segura, Durham, NC (US); Philip Scumpia, Los Angeles, CA (US); and Donald R. Griffin, Charlottesville, VA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Appl. No. 16/077,985
Filed by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
PCT Filed Feb. 14, 2017, PCT No. PCT/US2017/017837
§ 371(c)(1), (2) Date Aug. 14, 2018,
PCT Pub. No. WO2017/142879, PCT Pub. Date Aug. 24, 2017.
Claims priority of provisional application 62/295,933, filed on Feb. 16, 2016.
Prior Publication US 2020/0306413 A1, Oct. 1, 2020
Int. Cl. A61L 27/52 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 39/39 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); C08H 1/00 (2006.01); A61K 39/00 (2006.01)
CPC A61L 27/52 (2013.01) [A61K 9/0019 (2013.01); A61K 9/1635 (2013.01); A61K 9/1641 (2013.01); A61K 9/1652 (2013.01); A61K 39/39 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); C08H 1/00 (2013.01); A61K 2039/60 (2013.01); A61K 2039/6093 (2013.01); A61L 2300/426 (2013.01); A61L 2300/64 (2013.01); A61L 2400/06 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method of delivering a microgel system to a subject, the method comprising:
(a) delivering to the subject a plurality of microgel particles, wherein at least one microgel particle of the microgel particles comprises
(i) a core comprising one or more hydrogel polymer components; and
(ii) one or more annealing components in a presence of an annealing agent, wherein the one or more annealing components comprises a vinyl unsaturated double bond, a K-peptide, a Q-peptide, or any combination thereof; and
(b) exposing the plurality of microgel particles to the annealing agent, thereby coupling adjacent microgel particles of the plurality of microgel particles together, to form a covalently-stabilized scaffold of microgel particles comprising pores between the adjacent microgel particles, wherein the pores are on the 10 micrometer scale and are substantially devoid of the hydrogel polymer.