| CPC A61K 9/0051 (2013.01) [A61K 9/06 (2013.01); A61K 45/06 (2013.01); A61K 47/32 (2013.01); A61K 47/36 (2013.01)] | 25 Claims |
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1. A hydrogel ocular insert,
wherein the hydrogel ocular insert is placed into the cul-de-sac or conjunctival sac of an eye when being used by a patient and is made of a hydrogel material; and
wherein the hydrogel ocular insert is stored in a packaging aqueous solution in a sealed and sterilized package, wherein the packaging aqueous solution has a pH of from about 7.5 to about 9.0,
wherein the hydrogel material is a crosslinked polymeric material which is a crosslinking product of at least one arylborono-containing hydrophilic copolymer including arylborono-containing repeating units each having an arylborono group and at least one mucoadhesive polymer including repeating units each having a moiety selected from the group consisting of 1,2-diol moiety, 1,3-diol moiety, α-hydroxycarboxylic acid moiety, and β-hydroxycarboxylic acid moiety, wherein said at least one arylborono-containing hydrophilic copolymer and said at least one mucoadhesive polymer are crosslinked in the hydrogel material through crosslinks each formed between one of arylborono groups of said at least one arylborono-containing hydrophilic copolymer and one 1,2-diol, 1,3-diol, α-hydroxycarboxylic acid, or β-hydroxycarboxylic acid moiety of said at least one mucoadhesive polymer, and
wherein the hydrogel ocular insert has an on-eye dissolution time of from about 4 to about 24 hours.
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