US 11,931,391 B2
Methods for making botanical extract composition
Skye Doering, Minneapolis, MN (US); Dan S. Gaspard, Victoria, MN (US); Kristopher T. Mortenson, Victoria, MN (US); and Adam T. Zarth, St. Louis Park, MN (US)
Assigned to CARGILL, INCORPORATED, Wayzata, MN (US)
Filed by CARGILL, INCORPORATED, Wayzata, MN (US)
Filed on Apr. 27, 2022, as Appl. No. 17/660,848.
Application 17/660,848 is a continuation of application No. 17/224,847, filed on Apr. 7, 2021, granted, now 11,344,596.
Application 17/224,847 is a continuation of application No. PCT/US2020/026885, filed on Apr. 6, 2020.
Claims priority of provisional application 62/832,273, filed on Apr. 10, 2019.
Claims priority of provisional application 62/830,448, filed on Apr. 6, 2019.
Prior Publication US 2022/0249588 A1, Aug. 11, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 36/28 (2006.01); A23L 2/52 (2006.01); A23L 33/105 (2016.01); A61K 31/216 (2006.01); A61K 36/185 (2006.01); B01D 15/12 (2006.01); B01D 15/16 (2006.01); B01D 15/36 (2006.01); B01D 15/42 (2006.01)
CPC A61K 36/28 (2013.01) [A23L 2/52 (2013.01); A23L 33/105 (2016.08); A61K 31/216 (2013.01); A61K 36/185 (2013.01); B01D 15/125 (2013.01); B01D 15/161 (2013.01); B01D 15/363 (2013.01); B01D 15/426 (2013.01); A23V 2002/00 (2013.01); A61K 2236/31 (2013.01); A61K 2236/331 (2013.01); A61K 2236/333 (2013.01); A61K 2236/37 (2013.01); A61K 2236/39 (2013.01); A61K 2236/55 (2013.01)] 30 Claims
 
1. A method for making a caffeoylquinic composition, the method comprising:
i) contacting verba mate biomass, stevia biomass, or combinations thereof with a first aqueous composition comprising less than 30% (C1-C4)alkanol or free of (C1-C4)alkanol to obtain an initial extract;
ii) chromatographing the initial extract on an ion exchange stationary phase;
iii) eluting the stationary phase with a first aqueous elution composition comprising 10%-50% (C1-C4)alkanol to obtain a first eluent; and
iv) eluting the stationary phase with an acidified second aqueous elution composition comprising 60% to 80% (C1-C4)alkanol to obtain the caffeoylquinic composition,
wherein the caffeoylquinic composition comprises monocaffeoylquinic acid, dicaffeoylquinic acid, and salts of the foregoing; and
wherein the composition comprises less than 1% caffeine based on dry weight of the caffeoylquinic composition.