US 11,931,360 B2
Compositions and methods relating to inhibitors of pro-inflammatory factors for treatment of cancer
Isaac J. Powell, Detroit, MI (US); and Navnath S. Gavande, Rochester Hills, MI (US)
Assigned to Wayne State University, Detroit, MI (US)
Filed by Wayne State University, Detroit, MI (US)
Filed on Jun. 23, 2022, as Appl. No. 17/847,935.
Claims priority of provisional application 63/213,871, filed on Jun. 23, 2021.
Prior Publication US 2023/0018174 A1, Jan. 19, 2023
Int. Cl. A61K 31/506 (2006.01); A61K 45/06 (2006.01); C07D 401/14 (2006.01)
CPC A61K 31/506 (2013.01) [A61K 45/06 (2013.01); C07D 401/14 (2013.01)] 20 Claims
 
1. A compound comprising structural formula (I):

OG Complex Work Unit Chemistry
where X is O, NH, or S; where R1, R2, and R3, are each independently selected from the group consisting of H, Br, F, methyl, Cl, OH, CN, NH2, and CF3; where R4 is H, C1-C6 unsubstituted or substituted alkyl, cycloalkyl, aryl, phenyl, heteroalkyl, heterocycloalkyl, or heteroaryl; where R5 is COOH, CO2R, SO3H, SO2NH2, PO3H, CONH2, CONHOH, or SO2NHR where R is methyl, ethyl, CF3, CHF2, or CHF3; where HetAr is benzamidazolyl, benzoxazolyl, imidazopyridinyl, or imidazopyramidinyl; and where n1 is 0-2, n2 is 0-5, and n3 is 0-3; or a salt thereof.