US 11,927,521 B2
Analysis threshold determination device and analysis threshold determination method
Atsushi Saito, Yokohama (JP); Shigehiko Iwama, Yokohama (JP); and Masahiro Yamamoto, Yokohama (JP)
Assigned to JVCKENWOOD CORPORATION, Yokohama (JP)
Filed by JVCKENWOOD Corporation, Yokohama (JP)
Filed on Dec. 1, 2020, as Appl. No. 17/108,757.
Application 17/108,757 is a continuation of application No. PCT/JP2019/020063, filed on May 21, 2019.
Claims priority of application No. 2018-108516 (JP), filed on Jun. 6, 2018.
Prior Publication US 2021/0080373 A1, Mar. 18, 2021
Int. Cl. G01N 15/00 (2006.01); G01N 15/14 (2006.01); G01N 21/41 (2006.01); G01N 33/543 (2006.01); G01R 23/10 (2006.01); G01S 7/48 (2006.01); G01S 7/487 (2006.01)
CPC G01N 15/14 (2013.01) [G01N 21/41 (2013.01); G01N 33/543 (2013.01); G01R 23/10 (2013.01); G01S 7/4873 (2013.01)] 5 Claims
OG exemplary drawing
 
1. An analysis threshold determination device comprising:
an optical pickup configured to irradiate, with an irradiation light, an analysis substrate having a surface to which a detection target substance and a particle bound to the detection target substance are fixed, and receive a reflection light of the irradiation light from the analysis substrate to generate a light reception level signal;
a calculation unit configured to generate a pair of thresholds for a pulse width of a pulse included in the light reception level signal or a pair of thresholds for a pulse amplitude of the pulse;
a pulse determination unit configured to determine whether the pulse width is present within a range of the pair of thresholds for the pulse width or determine whether the pulse amplitude is present within a range of the pair of thresholds for the pulse amplitude;
a pulse count unit configured to count the pulse determined to be present within the range of the generated pair of thresholds by the pulse determination unit, and output a count value of the pulse counted; and
a threshold determination unit configured to determine a pair of or plural pairs of thresholds used for analysis in accordance with the pair of thresholds generated by the calculation unit and the count value output from the pulse count unit,
the calculation unit being configured to repeatedly generate a new pair of thresholds in which at least one of the pair of thresholds is changed every time the pulse count unit counts the pulse until reaching a predetermined value,
the threshold determination unit being configured to:
choose a class of a measure of central tendency according to a frequency distribution defining each pair of thresholds generated as a class and the count value output from the pulse count unit as a frequency; and
determine the pair of or plural pairs of thresholds corresponding to a class of a predetermined range from the class of the measure of central tendency.