US 11,927,509 B2
Particle sampling systems and methods for robotic controlled manufacturing barrier systems
Giovanni Scialo, Frascati (IT); and Davide Recchia, Frascati (IT)
Assigned to PARTICLE MEASURING SYSTEMS, INC., Boulder, CO (US)
Filed by Particle Measuring Systems, Inc., Boulder, CO (US)
Filed on Dec. 30, 2021, as Appl. No. 17/566,197.
Application 17/566,197 is a continuation of application No. 16/678,687, filed on Nov. 8, 2019, granted, now 11,255,760.
Claims priority of provisional application 62/831,343, filed on Apr. 9, 2019.
Claims priority of provisional application 62/768,365, filed on Nov. 16, 2018.
Prior Publication US 2022/0236146 A1, Jul. 28, 2022
Int. Cl. G01N 1/22 (2006.01); G01N 1/02 (2006.01); G01N 15/06 (2006.01); G01N 15/14 (2006.01); G01N 35/00 (2006.01); G01N 15/00 (2006.01)
CPC G01N 1/2247 (2013.01) [G01N 1/02 (2013.01); G01N 1/2202 (2013.01); G01N 15/0606 (2013.01); G01N 15/1459 (2013.01); G01N 35/0099 (2013.01); G01N 2001/2223 (2013.01); G01N 2001/2291 (2013.01); G01N 2015/0046 (2013.01); G01N 2015/0693 (2013.01); G01N 2015/1486 (2013.01)] 31 Claims
OG exemplary drawing
 
1. A system for detecting particles in a fluid, the system comprising:
a particle detection device comprising:
an impactor, the impactor comprising:
an inlet for receiving a particle-containing fluid, wherein at least some of the particles of the particle-containing fluid are biological particles;
a cover for covering the inlet
a sampling region for detecting particles in the fluid, the sampling region in fluid communication with the inlet; and
an outlet for discharging the fluid, the outlet in fluid communication with the sampling region; and
a robotic manipulator system comprising an optical detector or an imaging device, wherein the robotic manipulator is configured to perform at least one of the following steps:
transport the particle detection device to the sampling location;
remove the particle detection device from the sampling location; and
regulate a flow of fluid through the particle detection device;
and
wherein the robotic manipulator system is further configured to:
remove the cover to allow fluid to enter the inlet; and
optically detect cultured biological particles within the impactor via the robotic manipulator system.