	US 11,926,644 B2
	Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
Anthony Sauve, New Rochelle, NY (US); Farheen Sultana Mohammed, Jackson Heights, NY (US); and Yue Yang, New York, NY (US)
Assigned to Cornell University, Ithaca, NY (US)
Filed by Cornell University, Ithaca, NY (US)
Filed on Jul. 27, 2021, as Appl. No. 17/386,244.
Application 17/386,244 is a continuation of application No. 16/551,401, filed on Aug. 26, 2019, granted, now 11,098,076.
Application 16/551,401 is a continuation of application No. 15/744,602, granted, now 10,392,414, issued on Aug. 27, 2019, previously published as PCT/US2016/042600, filed on Jul. 15, 2016.
Claims priority of provisional application 62/192,917, filed on Jul. 15, 2015.
Prior Publication US 2021/0355152 A1, Nov. 18, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07H 19/048 (2006.01); A23L 33/10 (2016.01); A61K 31/706 (2006.01); C07H 1/00 (2006.01); C07H 1/06 (2006.01); C07H 19/04 (2006.01)

CPC C07H 19/048 (2013.01) [A23L 33/10 (2016.08); A61K 31/706 (2013.01); C07H 1/00 (2013.01); C07H 1/06 (2013.01); C07H 19/04 (2013.01); A23V 2002/00 (2013.01)]

20 Claims

1. A compound of formula (I):

wherein R¹, R², and R³are independently selected from hydrogen, formyl, optionally substituted C₁-C₁₂alkylcarbonyl, and optionally substituted C₆-C₁₀arylcarbonyl,

X is OR⁶, and

R⁶is hydrogen, optionally substituted C₁-C₁₂alkyl, or optionally substituted C₆-C₁₀aryl,

wherein the alkyl or aryl portion of R⁶is optionally substituted with one or more substituents selected from halo, amino, alkyl, alkoxy, aryloxy, hydroxyalkyl, and any combination thereof,

wherein the compound of formula (I) has an octanol-water partition coefficient (cLogP) of at least 0.11,

with the provisos that, when R⁶is hydrogen, R¹, R²,and R³are not all hydrogen or all acetyl,

when R⁶is hydrogen, R¹is not benzoyl and R²and R³are not hydrogen, and

when R⁶is methyl, ethyl, or propyl, R¹, R², and R³are not all acetyl, or a salt thereof.