US 11,926,574 B2
Dimethoxyphenylalkylamine activators of serotonin receptors
Glenn Short, Scituate, MA (US); Robert B. Perni, Marlborough, MA (US); Benjamin Robert Difrancesco, Toronto (CA); and Tanweer A. Khan, Bridgewater, NJ (US)
Assigned to Atai Therapeutics Inc., New York, NY (US)
Filed by Entheogenix Biosciences, Inc., Encinitas, CA (US)
Filed on Jun. 8, 2022, as Appl. No. 17/835,764.
Claims priority of provisional application 63/241,662, filed on Sep. 8, 2021.
Claims priority of provisional application 63/208,391, filed on Jun. 8, 2021.
Prior Publication US 2023/0138118 A1, May 4, 2023
Int. Cl. C07C 225/16 (2006.01); C07C 381/10 (2006.01)
CPC C07C 225/16 (2013.01) [C07C 381/10 (2013.01)] 21 Claims
 
1. A compound of Formula (II-B):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof; wherein,
R1 is independently at each position hydrogen, C1-C6 alkyl, or C1-C6 haloalkyl;
R2 and R3 are independently hydrogen, heterocycle, C1-C6 alkyl, C1-C6 haloalkyl, halogen, cyano, OR1, S(O)(═NH)R1, S(O)2R1, S(O)R1 or SR1, wherein at least one of R2 and R3 is hydrogen;
R4 is C1-C6 alkyl; and
R5 is halogen.