US 11,925,806 B2
Brain stimulation therapy
Jonathon E. Giftakis, Maple Grove, MN (US); and Paul H. Stypulkowski, North Oaks, MN (US)
Assigned to Medtronic, Inc., Minneapolis, MN (US)
Filed by Medtronic, Inc., Minneapolis, MN (US)
Filed on Jul. 28, 2020, as Appl. No. 16/941,085.
Application 16/036,439 is a division of application No. 14/920,468, filed on Oct. 22, 2015, granted, now 10,052,485, issued on Aug. 21, 2018.
Application 16/941,085 is a continuation of application No. 16/036,439, filed on Jul. 16, 2018, granted, now 10,729,908.
Prior Publication US 2020/0353262 A1, Nov. 12, 2020
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01)
CPC A61N 1/36139 (2013.01) [A61N 1/0534 (2013.01); A61N 1/36082 (2013.01); A61N 1/36096 (2013.01); A61N 1/36171 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A method comprising:
delivering, via a plurality of electrodes implanted in a brain of a patient, electrical stimulation to a stimulation site of the brain of the patient, wherein the stimulation site comprises a neural connection to a target site of the brain of the patient, and wherein the stimulation site comprises a Fornix of the brain of the patient;
sensing, via the plurality of electrodes and from the target site, bioelectrical brain activity comprising a bioelectrical response to the delivery of the electrical stimulation, the bioelectrical response overlapping in time with at least a portion of the delivery of the electrical stimulation;
detecting, by processing circuitry, a biomarker in the bioelectrical response, the biomarker occurring during the delivery of the electrical stimulation;
determining, by the processing circuitry, at least one parameter value of subsequent electrical stimulation based on the detected biomarker; and
delivering, via the plurality of electrodes, the subsequent electrical stimulation according to the determined at least one parameter value to the stimulation site to achieve a patient state in the target site.