US 11,925,728 B2
Degradable vascular stent capable of avoiding late restenosis
Zheng Wei, Shanghai (CN); Bin Huang, Shanghai (CN); Jian Xie, Shanghai (CN); and Yunhong Mu, Shanghai (CN)
Assigned to Shandong Huaan Biotechnology Co., Ltd., Jinan (CN)
Appl. No. 16/960,258
Filed by Shanghai Weite Biotecnnology Co., Ltd, Shanghai (CN)
PCT Filed Jan. 9, 2018, PCT No. PCT/CN2018/071913
§ 371(c)(1), (2) Date Jul. 6, 2020,
PCT Pub. No. WO2019/136593, PCT Pub. Date Jul. 18, 2019.
Prior Publication US 2021/0069384 A1, Mar. 11, 2021
Int. Cl. A61F 2/06 (2013.01); A61F 2/90 (2013.01); A61L 27/18 (2006.01); A61L 27/26 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01)
CPC A61L 27/54 (2013.01) [A61F 2/06 (2013.01); A61F 2/90 (2013.01); A61L 27/18 (2013.01); A61L 27/26 (2013.01); A61L 27/58 (2013.01); A61F 2210/0004 (2013.01); A61F 2250/0068 (2013.01); A61L 2300/41 (2013.01); A61L 2300/412 (2013.01); A61L 2300/42 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A degradable vascular stent capable of avoiding late restenosis, comprising:
a base region formed by a polylactic acid based polymer; at least one storage region in which an active agent is stored; and
an outer layer of a drug sustained release coating covered on the base region and/or the storage region;
wherein before the mass of the polylactic acid based polymer of the base region is decreased by 10-20%, the active agent in the storage region is retained in structural units of the polylactic acid based polymer;
wherein after the mass of the polylactic acid based polymer of the base region is decreased by 10-20%, the active agent in the storage region is released from the storage region;
wherein the storage region is formed of an alkaline degradable polymer or a mixture of a polylactic acid based polymer and an alkaline degradable polymer; and
wherein after the mass of the polymer of the base region is decreased by 10-20%, the alkaline degradable polymer is hydrolyzed to release alkaline monomers.