	US 11,925,712 B2
	Implantable devices for delivery of bioactive agents
Jeremy Ollerenshaw, Alpharetta, GA (US); Emily Reichart, Milford, OH (US); and Russell F. Ross, Atlanta, GA (US)
Assigned to SORRENTO THERAPEUTICS, INC., San Diego, CA (US)
Filed by SORRENTO THERAPEUTICS, INC., San Diego, CA (US)
Filed on Aug. 2, 2021, as Appl. No. 17/391,602.
Application 17/391,602 is a continuation of application No. 14/354,223, granted, now 11,110,066, previously published as PCT/IB2012/055622, filed on Oct. 16, 2012.
Claims priority of provisional application 61/552,059, filed on Oct. 27, 2011.
Prior Publication US 2021/0401764 A1, Dec. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/70 (2006.01); A61K 9/00 (2006.01); A61L 27/50 (2006.01); A61L 27/54 (2006.01); A61L 31/14 (2006.01); A61L 31/16 (2006.01); A61M 37/00 (2006.01); A61F 2/00 (2006.01); A61F 2/82 (2013.01)

CPC A61K 9/7007 (2013.01) [A61K 9/0024 (2013.01); A61K 9/0097 (2013.01); A61L 27/50 (2013.01); A61L 27/54 (2013.01); A61L 31/14 (2013.01); A61L 31/16 (2013.01); A61M 37/0015 (2013.01); A61F 2002/0081 (2013.01); A61F 2/82 (2013.01); A61F 2250/0067 (2013.01); A61L 2400/12 (2013.01); A61L 2400/18 (2013.01); A61M 2037/0053 (2013.01)]

20 Claims

1. A fully implantable delivery device for delivery of a bioactive agent to a subject, the device comprising:

the bioactive agent;

a wall having a surface;

a plurality of nanostructures extending from the surface of the wall, and a plurality of microstructures extending from the surface of the wall,

wherein the plurality of nanostructures and plurality of microstructures are arranged in a fractal dimension of greater than about 1.