| CPC A61K 47/59 (2017.08) [A61K 38/09 (2013.01); A61P 35/00 (2018.01); C08G 73/0233 (2013.01)] | 18 Claims |
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1. A heterofunctional polyoxazoline derivative of the general structure I:
R1—{[N(COX)CH2CH2]n—[N(COR2)CH2—CH2)]n—[N(COY)CH2—CH2)]m}a—Z
wherein:
R1 is an initiating group;
R2 is independently selected for each repeating unit from an unsubstituted or substituted alkyl, an unsubstituted or substituted alkenyl, an unsubstituted or substituted aralkyl or an unsubstituted or substituted heterocyclylalkyl group;
X is a pendent moiety containing a first functional group and the first functional group is selected from the group consisting of: an alkyne, an amine, an oxyamine, an aldehyde, a ketone, an acetal, a ketal, an ester, a carboxylic acid, an activated carboxylic acid, an active carbonate, a chloroformate, an alcohol, an azide, a vinyl sulfone, a maleimide and orthopyridyl disulfide;
Y is a pendent moiety containing a second functional group and the second functional group is selected from the group consisting of: an alkyne, an amine, an oxyamine, an aldehyde, a ketone, an acetal, a ketal, an ester, a carboxylic acid, an activated carboxylic acid, an active carbonate, a chloroformate, an alcohol, an azide, a vinyl sulfone, a maleimide and orthopyridyl disulfide;
Z is a terminating nucleophile;
a is ran which indicates a random copolymer or block which indicates a block copolymer;
o and m are each an integer independently selected from 1-50; and
n is an integer selected from 0-1000;
wherein the heterofunctional polyoxazoline derivative is linked to at least one target molecule, through at least one of the first or second functional groups.
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