CPC A61K 31/7024 (2013.01) [A61P 35/00 (2018.01); A61P 35/04 (2018.01)] | 32 Claims |
1. A method of treating a proliferative disease chosen from squamous cell carcinoma and lung adenocarcinoma by inhibiting glycolysis in glycolytic tumor cells in a patient in need thereof comprising administering a therapeutically effective amount of one or more compounds of the Formula I:
or a salt, ester or prodrug thereof, wherein:
each R1, R2, R3 and R4 are independently H, or COR5;
at least one of R1, R2, R3 and R4 is COR5; and
each R5 is independently selected from the group C3-C10 straight- or branched-chain alkyl, C4-C10 alkylcycloalkyl, and C3-C10 cycloalkyl.
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