	US 11,925,644 B2
	Crystalline salts of 5-methyl-(6S)-tetrahydrofolic acid and l-leucine ethyl ester
Rudolf Moser, Schaffhausen (CH); Viola Groehn, Dachsen (CH); Ruth Boehni Stamm, Stein Am Rhein (CH); Fritz Blatter, Reinach (CH); and Martin Szelagiewicz, Basel (CH)
Assigned to MERCK PATENT GMBH, Darmstadt (DE)
Appl. No. 17/258,086
Filed by MERCK PATENT GMBH, Darmstadt (DE)
PCT Filed Jul. 2, 2019, PCT No. PCT/EP2019/067698 § 371(c)(1), (2) Date Jan. 5, 2021, PCT Pub. No. WO2020/007839, PCT Pub. Date Jan. 9, 2020.
Claims priority of application No. 18182279 (EP), filed on Jul. 6, 2018.
Prior Publication US 2021/0283136 A1, Sep. 16, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/519 (2006.01); A61K 9/14 (2006.01); A61K 47/14 (2017.01); C07D 487/04 (2006.01)

CPC A61K 31/519 (2013.01) [A61K 9/145 (2013.01); A61K 47/14 (2013.01); C07D 487/04 (2013.01); C07B 2200/13 (2013.01)]

13 Claims

1. A crystalline salt comprising 5-methyl-(6S)-tetrahydrofolic acid and L-leucine ethyl ester, wherein the molar ratio of 5-methyl-(6S)-tetrahydrofolic acid to L-leucine ethyl ester is 1:0.75 to 1:1.25 (in mol/mol) or a hydrate or solvate thereof.