US 11,925,633 B2
Drug for preventing and/or treating dementia
Tadamasa Matsumoto, Tokyo (JP); Masafumi Ihara, Suita (JP); Satoshi Saito, Suita (JP); and Masanori Fukushima, Kobe (JP)
Assigned to NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, Suita (JP)
Filed by NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, Suita (JP)
Filed on Dec. 18, 2020, as Appl. No. 17/126,488.
Application 17/126,488 is a division of application No. 16/302,097, abandoned, previously published as PCT/JP2017/017195, filed on May 1, 2017.
Claims priority of application No. 2016-100092 (JP), filed on May 19, 2016.
Prior Publication US 2021/0100790 A1, Apr. 8, 2021
Int. Cl. A61K 31/4709 (2006.01); A61K 31/353 (2006.01); A61P 25/28 (2006.01)
CPC A61K 31/4709 (2013.01) [A61K 31/353 (2013.01); A61P 25/28 (2018.01)] 9 Claims
 
1. A method for improving memory disorders and behavioral and psychological symptoms of dementia (BPSD) in a patient with dementia comprising administering to the patient a combination of an effective amount of (a) a carbostyril derivative represented by formula (1)

OG Complex Work Unit Chemistry
wherein R is a cycloalkyl group, A is a lower alkyl group, and a single bond or a double bond is present between the 3-position and the 4-position of the carbostyril nucleus, or a salt thereof, and (b) an effective amount of dihydroquercetin or a salt thereof.