CPC A61K 31/198 (2013.01) [A61K 9/2009 (2013.01); A61K 9/2013 (2013.01); A61K 9/2054 (2013.01); A61K 9/2095 (2013.01); A61K 9/2813 (2013.01); A61K 9/2853 (2013.01); A61K 9/2866 (2013.01); A61K 31/192 (2013.01)] | 19 Claims |
1. A method of producing a single dosage unit tablet comprising (a) about 375 mg of eflornithine hydrochloride monohydrate, (b) about 75 mg of sulindac, and (c) about 1 to about 1.5 weight percent magnesium stearate comprising:
(a) pre-mixing the sulindac and a first excipient to form a first mixture;
(b) mixing the first mixture with a second mixture comprising eflornithine hydrochloride monohydrate and a second excipient to form a blend;
(c) screening the blend to form a granulated blend;
(d) adding magnesium stearate to the granulated blend to obtain a final blend; and
(e) applying a compression force to the final blend to form the tablet.
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