US 11,925,485 B2
Non-invasive system for monitoring and treating respiratory distress
Elizabeth Mary Annoni, White Bear Lake, MN (US); Bryan Allen Clark, Forest Lake, MN (US); Jeffrey E. Stahmann, Ramsey, MN (US); and Viktoria A. Averina, Shoreview, MN (US)
Assigned to Cardiac Pacemakers, Inc., St. Paul, MN (US)
Filed by Cardiac Pacemakers, Inc., St. Paul, MN (US)
Filed on Nov. 8, 2018, as Appl. No. 16/184,020.
Claims priority of provisional application 62/595,166, filed on Dec. 6, 2017.
Prior Publication US 2019/0167209 A1, Jun. 6, 2019
Int. Cl. A61B 5/00 (2006.01); A61B 5/0205 (2006.01); A61B 5/08 (2006.01); A61B 5/085 (2006.01); A61B 5/11 (2006.01)
CPC A61B 5/7282 (2013.01) [A61B 5/0022 (2013.01); A61B 5/0205 (2013.01); A61B 5/0816 (2013.01); A61B 5/0823 (2013.01); A61B 5/0826 (2013.01); A61B 5/085 (2013.01); A61B 5/4809 (2013.01); A61B 5/4836 (2013.01); A61B 5/6833 (2013.01); A61B 5/746 (2013.01); A61B 5/1118 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for monitoring and treating respiratory distress in a patient, comprising:
one or more non-invasive monitoring devices configured to acquire patient condition signals indicative of a state of the respiratory distress, the patient condition signals including a blood pressure signal indicative of a blood pressure of the patient, a cardiac signal indicative of cardiac cycles of the patient, and a respiratory signal indicative of inspiration and expiration phases of the patient; and
a respiratory distress monitoring circuit figured to be communicatively coupled to the one or more non-invasive monitoring devices and to monitor the state of the respiratory distress using the patient condition signals, the respiratory distress monitoring circuit including:
a signal processing circuit configured to process the patient condition signals and to generate patient condition parameters indicative of the state of the respiratory distress using the processed patient condition signals, the patient condition parameters including a physical state parameter and a baroreflex sensitivity (BRS) parameter, the physical state parameter indicating a physical state of the patient including at least the inspiration and expiration phases and generated using the respiratory signal, the BRS parameter being a measure of the BRS of the patient and generated using the blood pressure signal and the cardiac signal; and
a respiratory distress analyzer including a parameter analysis circuit and a notification circuit, the parameter analysis circuit configured to produce a patient condition metric being a linear or nonlinear function of the patient condition parameters including the BRS parameter stratified by values of the physical state parameter including the inspiration and expiration phases and to perform at least one of prediction or detection of an exacerbation of the respiratory distress based on the patient condition metric, the notification circuit configured to produce an alert notifying a result of the performance of the at least one of prediction or detection.