US 11,925,484 B2
Alert system for hypo and hyperglycemia prevention based on clinical risk
Giovanni Sparacino, Padua (IT); Claudio Cobelli, Padua (IT); Stefania Guerra, Carre (IT); Andrea Facchinetti, Padua (IT); and Michele Schiavon, Chioggia (IT)
Assigned to Dexcom, Inc., San Diego, CA (US)
Filed by Dexcom, Inc., San Diego, CA (US)
Filed on Jun. 23, 2022, as Appl. No. 17/808,377.
Application 17/808,377 is a continuation of application No. 16/427,100, filed on May 30, 2019, granted, now 11,412,992.
Application 16/427,100 is a continuation of application No. 15/239,712, filed on Aug. 17, 2016, granted, now 10,357,207, issued on Jul. 23, 2019.
Application 15/239,712 is a continuation of application No. 13/661,393, filed on Oct. 26, 2012, granted, now 9,439,602, issued on Sep. 13, 2016.
Claims priority of provisional application 61/551,773, filed on Oct. 26, 2011.
Prior Publication US 2022/0313173 A1, Oct. 6, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01); G16H 50/30 (2018.01)
CPC A61B 5/7275 (2013.01) [A61B 5/14532 (2013.01); A61B 5/743 (2013.01); A61B 5/746 (2013.01); G16H 50/30 (2018.01); A61B 5/7405 (2013.01); A61B 5/7455 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A system for alerting a patient of hypoglycemia and/or hyperglycemia risk, the system comprising:
(a) a continuous glucose monitoring (CGM) device configured to periodically perform glucose measurements for the patient, thereby generating a series of glucose values;
(b) one or more circuitries configured to:
determine a signal to noise ratio (SNR) associated with the periodic glucose measurements;
upon determining that the SNR is at a first SNR level, evaluate, using a first algorithm, a differential change in glucose value over time (dg/dt) based on the series of glucose values;
upon determining that the SNR is at a second SNR level, evaluate, using a second algorithm, the differential change in glucose value over time (dg/dt) based on the series of glucose values, wherein the first SNR level is lower than the second SNR level;
generate a smoothed glucose value that is indicative of the series of glucose values;
estimate a dynamic risk based on the smoothed glucose value and dg/dt;
compare the dynamic risk to a predetermined threshold; and
generate a display representative of the smoothed glucose value and a perceptible alarm when the dynamic risk is greater than the predetermined threshold.