US 11,925,455 B2
Methods for diagnosing malaria
Audrey Odom John, St. Louis, MO (US); Chad Schaber, St. Louis, MO (US); Indi Trehan, St. Louis, MO (US); Baranidharan Raman, St. Louis, MO (US); and Nalin Katta, Boston, MA (US)
Assigned to Washington University, St. Louis, MO (US)
Appl. No. 16/641,501
Filed by Washington University, St. Louis, MO (US)
PCT Filed Aug. 27, 2018, PCT No. PCT/US2018/048146
§ 371(c)(1), (2) Date Feb. 24, 2020,
PCT Pub. No. WO2019/040937, PCT Pub. Date Feb. 28, 2019.
Claims priority of provisional application 62/550,283, filed on Aug. 25, 2017.
Prior Publication US 2021/0128016 A1, May 6, 2021
Int. Cl. A61B 5/08 (2006.01); A01N 27/00 (2006.01); A61B 5/00 (2006.01); A61B 10/00 (2006.01); G01N 33/497 (2006.01)
CPC A61B 5/082 (2013.01) [A01N 27/00 (2013.01); A61B 5/7246 (2013.01); A61B 5/7264 (2013.01); A61B 5/7282 (2013.01); G01N 33/497 (2013.01); A61B 2010/0087 (2013.01); A61B 2560/0431 (2013.01); G01N 2033/4975 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A method for monitoring a subject with a Plasmodium parasite infection (malaria), the method comprising:
analyzing a sample of exhaled breath or condensate breath obtained from the subject for a series of volatile organic compounds (VOCs) comprising:
(1) isoprene,
(2) nonanal,
(3) tridecane,
(4) 4-methyl undecane,
(5) 3,7-dimethyl decane, and
(6) 2,3,4-trimethyl hexane;
determining a concentration for each of the VOCs; and
calculating a cumulative abundance based on the concentrations for the VOCs, wherein the cumulative abundance indicates a Plasmodium parasite infection.
 
4. A method of detecting a series of volatile organic compounds (VOCs) in a subject, the method comprising analyzing a sample of exhaled breath or condensate breath obtained from the subject for the series of VOCs comprising:
(1) isoprene,
(2) nonanal,
(3) tridecane,
(4) 4-methyl undecane,
(5) 3,7-dimethyl decane, and
(6) 2,3,4-trimethyl hexane; and
determining a concentration for each of the VOCs.