US 11,915,361 B2
System, method, and computer program product for predicting, anticipating, and/or assessing tissue characteristics
Martin Rohrer, Berlin (DE); Gesine Knobloch, Berlin (DE); and Arthur Uber, III, Pittsburgh, PA (US)
Assigned to BAYER AKTIENGESELLSCHAFT, Leverkusen (DE)
Appl. No. 17/753,564
Filed by BAYER AKTIENGESELLSCHAFT, Leverkusen (DE)
PCT Filed Sep. 17, 2020, PCT No. PCT/IB2020/058688
§ 371(c)(1), (2) Date Mar. 8, 2022,
PCT Pub. No. WO2021/053585, PCT Pub. Date Mar. 25, 2021.
Claims priority of provisional application 62/943,969, filed on Dec. 5, 2019.
Claims priority of application No. 19197989 (EP), filed on Sep. 18, 2019.
Prior Publication US 2022/0414972 A1, Dec. 29, 2022
Int. Cl. G06K 9/00 (2022.01); G06T 15/08 (2011.01); G06V 10/62 (2022.01); G06T 7/00 (2017.01)
CPC G06T 15/08 (2013.01) [G06T 7/0016 (2013.01); G06V 10/62 (2022.01); G06T 2207/30024 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A computer-implemented method comprising:
obtaining measurement information associated with a parameter of a voxel of an image of tissue of a patient, wherein the measurement information is measured at two or more time points to provide first measurement information associated with the parameter of the voxel at a first time point of the two or more time points and second measurement information associated with the parameter of the voxel at a second time point of the two or more time points, wherein the two or more time points occur before one or more tissue characteristics are separable or discernible in another image generated based on the parameter of the voxel measured at a time point, and wherein the one or more tissue characteristics comprise:
a concentration of contrast agent in arteries;
a concentration of contrast agent in veins;
a concentration of contrast agent in cells;
a summed enhancement of a concentration of contrast agent in arteries, veins, and cells;
one or more pharmacokinetic parameters associated with contrast agent movement through tissue spaces; or
any combination thereof; and
determining one or more characteristics of the voxel of the image of tissue based on the first measurement information associated with the parameter of the voxel at the first time point, the second measurement information associated with the parameter of the voxel at the second time point, and a desired rate and/or plateau level of a concentration of a contrast agent delivered to the patient.