US 11,913,957 B2
Compositions, methods and kits for diagnosis of lung cancer
Paul E. Kearney, Seattle, WA (US); Kenneth C. Fang, San Francisco, CA (US); Xiao-Jun Li, Bellevue, WA (US); Clive Hayward, Seattle, WA (US); and Douglas Spicer, Enumclaw, WA (US)
Assigned to Biodesix, Inc., Boulder, CO (US)
Filed by Biodesix, Inc., Boulder, CO (US)
Filed on Oct. 18, 2017, as Appl. No. 15/786,924.
Application 15/786,924 is a continuation in part of application No. 15/051,153, filed on Feb. 23, 2016, granted, now 10,338,074.
Application 15/051,153 is a continuation of application No. 13/775,494, filed on Feb. 25, 2013, granted, now 9,304,137.
Application 13/775,494 is a continuation in part of application No. 13/724,823, filed on Dec. 21, 2012, granted, now 9,201,044.
Claims priority of provisional application 61/725,153, filed on Nov. 12, 2012.
Claims priority of provisional application 61/676,859, filed on Jul. 27, 2012.
Claims priority of provisional application 61/589,920, filed on Jan. 24, 2012.
Claims priority of provisional application 61/578,712, filed on Dec. 21, 2011.
Prior Publication US 2018/0067119 A1, Mar. 8, 2018
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/574 (2006.01); G01N 33/68 (2006.01); G01N 33/53 (2006.01); G16B 20/00 (2019.01); G16B 40/00 (2019.01)
CPC G01N 33/57423 (2013.01) [G01N 33/6893 (2013.01); G01N 33/53 (2013.01); G01N 33/6848 (2013.01); G16B 20/00 (2019.02); G16B 40/00 (2019.02)] 12 Claims
 
1. A method of treating a pulmonary nodule in a subject, comprising:
(a) performing an immunoassay to measure expression levels of a panel of proteins present in a blood sample of the subject, wherein the panel comprises LG3BP and C163A;
(b) determining a probability of lung cancer score based on the measurements of step (a); and
(c) treating the subject having a score in step (b) that is equal to or greater than a predetermined score by surgery, chemotherapy, radiotherapy, or any combination thereof.