US 11,913,058 B2
Devices, systems and methods to detect viable infectious agents in a fluid sample and susceptibility of infectious agents to anti-infectives
Oren S. Knopfmacher, San Francisco, CA (US); Meike Herget, Woodside, CA (US); Michael D. Laufer, Menlo Park, CA (US); and August Estabrook, South San Francisco, CA (US)
Assigned to Avails Medical, Inc., Menlo Park, CA (US)
Filed by Avails Medical, Inc., Menlo Park, CA (US)
Filed on Apr. 28, 2021, as Appl. No. 17/242,810.
Application 17/242,810 is a continuation of application No. 16/241,691, filed on Jan. 7, 2019, granted, now 11,021,732.
Application 16/241,691 is a continuation of application No. 15/482,307, filed on Apr. 7, 2017, granted, now 10,174,356, issued on Jan. 8, 2019.
Claims priority of provisional application 62/343,564, filed on May 31, 2016.
Prior Publication US 2021/0246484 A1, Aug. 12, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C12Q 1/18 (2006.01); C12Q 1/00 (2006.01); C12Q 1/02 (2006.01); C12Q 1/04 (2006.01); G01N 27/27 (2006.01); G01N 27/327 (2006.01); G01N 33/50 (2006.01); B01L 3/00 (2006.01)
CPC C12Q 1/18 (2013.01) [C12Q 1/006 (2013.01); C12Q 1/025 (2013.01); C12Q 1/04 (2013.01); G01N 27/27 (2013.01); G01N 27/3273 (2013.01); G01N 27/3275 (2013.01); G01N 33/5011 (2013.01); B01L 3/502715 (2013.01); G01N 27/3272 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of assessing a susceptibility of an infectious agent to an anti-infective, the method comprising:
introducing a fluid sample to a first surface and a second surface;
exposing the first surface comprising the infectious agent to a first solution;
exposing the second surface comprising the infectious agent to a second solution, wherein at least one of the second surface and the second solution comprises an anti-infective;
monitoring a first electrical characteristic of a first sensing device exposed to the first solution;
monitoring a second electrical characteristic of a second sensing device exposed to the second solution; and
comparing the first electrical characteristic with the second electrical characteristic, wherein any differences between the first electrical characteristic and the second electrical characteristic, or lack thereof, is used to assess the susceptibility of the infectious agent to the anti-infective.