US 11,912,975 B2
Electroporation apparatus and method
Declan Soden, Clonakilty (IE); Colin Forde, Kinvara (IE); Sean Kinsella, Oranmore (IE); and Tony Moore, Ballincollig (IE)
Assigned to MIRAI MEDICAL LIMITED, Oranmore (IE)
Appl. No. 17/636,649
Filed by MIRAI MEDICAL LIMITED, Oranmore (IE)
PCT Filed Sep. 1, 2020, PCT No. PCT/EP2020/074374
§ 371(c)(1), (2) Date Feb. 18, 2022,
PCT Pub. No. WO2021/043779, PCT Pub. Date Mar. 11, 2021.
Claims priority of application No. 19194958 (EP), filed on Sep. 2, 2019; application No. 19194959 (EP), filed on Sep. 2, 2019; and application No. 20168567 (EP), filed on Apr. 7, 2020.
Prior Publication US 2022/0298464 A1, Sep. 22, 2022
Int. Cl. C12M 1/42 (2006.01); A61N 1/32 (2006.01); A61B 18/00 (2006.01)
CPC C12M 35/02 (2013.01) [A61N 1/327 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/00875 (2013.01)] 22 Claims
OG exemplary drawing
 
1. An electroporation apparatus comprising:
a plurality of electroporation probe terminals;
a transformer for providing stepped-up voltage,
a switching circuit with switches for linking high voltage and low voltage or ground levels to the probe terminals; and
a controller configured to control said switches according to a control scheme to deliver pulses to the probe terminals, and in which said pulses are delivered to groups of at least two probe electrode terminals for probe electrodes which are spaced apart, and
wherein the controller is configured to apply a ramp-up (tr) duration of less than 0.5 μs to a plateau amplitude in the range of 100V to 3000V for a duration in the range of 1 μs to 5 μs, and a ramp-down (tf) duration from said voltage of less than 0.5 μs for each probe electrode terminal.