US 11,912,973 B2
Facilitating cell growth using a dynamic scaffold
Zheng Huang, Bolton, MA (US); Orianna Elysse Kane, Boston, MA (US); Xiaoting Liang, Columbus, OH (US); and Natalie Rose Rubio, Malden, MA (US)
Assigned to Ark Biotech Inc., Westwood, MA (US)
Filed by Ark Biotech Inc., Westwood, MA (US)
Filed on Jun. 1, 2023, as Appl. No. 18/204,603.
Claims priority of provisional application 63/392,612, filed on Jul. 27, 2022.
Prior Publication US 2024/0034977 A1, Feb. 1, 2024
Int. Cl. C12M 1/12 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01)
CPC C12M 25/14 (2013.01) [C12M 23/40 (2013.01); C12M 41/44 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A bioreactor, comprising:
a scaffold seeded with a plurality of cells and having an extended state and a non-extended state;
a scaffold support that selectively modifies a state of the scaffold from the non-extended state to the extended state; and
a manifold configured to provide a medium to the scaffold, wherein the scaffold support modifies the state of the scaffold from the non-extended state to the extended state at a rate tuned to maintain a cell density associated with the plurality of cells within a particular density range.