| CPC C07D 471/04 (2013.01) | 18 Claims |
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1. A compound having formula (Id)
 wherein
R1 is H or alkyl;
R2 is H or alkyl;
R4 is H, or alkyl;
R6 is H, or alkyl;
Rw is —NR10SO2R12;
R10 is H, alkyl, or phenylalkyl;
R12 is H, alkyl, haloalkyl or phenylalkyl, wherein the phenyl group is optionally substituted with 1 or 2 groups independently selected from alkyl and halogen;
Rx Ry, and Rz are selected from:
a) Rx and Ry are F and Rz is H; and
b) Rx, Ry and Rz are F;
R5 is selected from
(a) phenyl which is substituted with 1, 2 or 3 groups independently selected from
halogen,
alkyl,
alkoxy,
alkoxy wherein the alkyl group is substituted with 1, 2 or 3 hydroxy groups,
haloalkyl,
hydroxy,
—SO2NR10R10,
—CO2R10,
—CN,
—SF5,
—(NR10═)S(═O)-alkyl (S-alkyl sulfonimidoyl), and
1H- or 2H-tetrazolyl;
(b) naphthyl;
(c) a heteroaromatic 5- or 6-membered monocyclic group having 1 or 2 heteroatoms independently selected from O, N and S, wherein the heteroaromatic group is optionally substituted with 1, 2 or 3 groups independently selected from
alkyl,
haloalkyl,
cycloalkyl,
halogen,
hydroxy,
alkoxy, which is optionally substituted with —NR10R10,
—CN,
alkenyl,
alkynyl,
R10R10N—CO—)
alkyl-S(═O)(═NR10)—,
cycloalkyl-NR10—,
alkyl-NR10—, wherein the alkyl group is substituted with hydroxy or alkoxy,
alkylsulfanyl,
benzimidazolyl,
and
a non-aromatic heterocyclic 4-, 5- or 6-membered monocyclic group having 1 or 2 heteroatoms independently selected from O, and N, which heterocyclic group is optionally substituted with alkyl, hydroxyalkyl or hydroxy; and
(d) cycloalkyl,
or a pharmaceutically acceptable salt, solvate or optical isomer thereof.
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