US 11,912,691 B2
Tocotrienols derivates, methods and uses thereof
Daniel Kern, Reno, NV (US); Kent Mirkhani, Reno, NV (US); Ivo Manuel Ascensão Aroso, Perafita (PT); Ricardo De Sá Bessa, Matosinhos (PT); and Rui Luis Goncalves Dos Reis, Oporto (PT)
Assigned to GLOBAL SCIENTIFIC, Reno, NV (US)
Appl. No. 18/030,775
Filed by GLOBAL SCIENTIFIC, Reno, NV (US)
PCT Filed Oct. 8, 2021, PCT No. PCT/IB2021/059248
§ 371(c)(1), (2) Date Apr. 7, 2023,
PCT Pub. No. WO2022/074622, PCT Pub. Date Apr. 14, 2022.
Claims priority of application No. 20200872 (EP), filed on Oct. 8, 2020.
Prior Publication US 2023/0271948 A1, Aug. 31, 2023
Int. Cl. C07D 405/12 (2006.01); A61K 8/67 (2006.01); A61Q 19/08 (2006.01)
CPC C07D 405/12 (2013.01) [A61K 8/678 (2013.01); A61Q 19/08 (2013.01)] 14 Claims
 
1. A compound of the following general formula (I)

OG Complex Work Unit Chemistry
wherein
R1, R2, R3 and R4 are independently selected from each other;
R1 is H or CH3;
R2 is H or CH3;
R3 is H or CH3;
R4 is selected from

OG Complex Work Unit Chemistry
 and
R5 is a glycolic diester residue, succinic diester residue, or a glycine amide ester residue.