US 11,911,762 B2
Biomarker detection using integrated purification-detection devices
Joshua T. Smith, Croton on Hudson, NY (US); Benjamin Wunsch, Mt. Kisco, NY (US); Stacey Gifford, Ridgefield, CT (US); and Sung-Cheol Kim, New York, NY (US)
Assigned to INTERNATIONAL BUSINESS MACHINES CORPORATION, Armonk, NY (US)
Filed by International Business Machines Corporation, Armonk, NY (US)
Filed on May 7, 2021, as Appl. No. 17/314,496.
Application 17/314,496 is a continuation of application No. 16/168,228, filed on Oct. 23, 2018, granted, now 11,033,901.
Prior Publication US 2021/0260586 A1, Aug. 26, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. B01L 3/00 (2006.01); G06T 7/00 (2017.01)
CPC B01L 3/502753 (2013.01) [G06T 7/0012 (2013.01); B01L 2300/0654 (2013.01)] 20 Claims
OG exemplary drawing
 
11. A method comprising:
isolating target particles from other particles included in a biological fluid sample using a separation unit comprising nanoscale deterministic lateral displacement arrays formed on a microfluidic chip in fluid communication with an inlet bus formed around a perimeter of a first side of the nanoscale deterministic displacement arrays;
collecting, as a result of the isolating, the target particles in an outlet bus formed on a second side of the nanoscale deterministic displacement arrays opposite the first side; and
driving flow of a buffer fluid comprising the target particles from the outlet bus to a sensing element of the microfluidic chip configured to facilitate detecting presence of one or more biomarkers associated with the target particles, wherein the outlet bus surrounds the detection unit and supplies the particles of interest onto the sensing element.