US 11,911,508 B2
Microparticles containing dutasteride, and preparation method therefor
Ju Hee Kim, Seongnam-si (KR); and Se Yeon Kim, Suwon-Si (KR)
Assigned to INVENTAGE LAB INC., Seongnam-si (KR)
Appl. No. 17/056,711
Filed by INVENTAGE LAB INC., Seongnam-si (KR)
PCT Filed May 20, 2019, PCT No. PCT/KR2019/005986
§ 371(c)(1), (2) Date Nov. 18, 2020,
PCT Pub. No. WO2019/225924, PCT Pub. Date Nov. 28, 2019.
Claims priority of application No. 10-2018-0057696 (KR), filed on May 21, 2018; and application No. 10-2019-0056391 (KR), filed on May 14, 2019.
Prior Publication US 2021/0205221 A1, Jul. 8, 2021
Int. Cl. A61K 9/16 (2006.01); A61K 31/58 (2006.01); A61K 47/34 (2017.01)
CPC A61K 9/167 (2013.01) [A61K 31/58 (2013.01); A61K 47/34 (2013.01)] 6 Claims
OG exemplary drawing
 
1. Dutasteride-containing microparticles, comprising dutasteride and a biodegradable polymer,
wherein,
the microparticles have a dutasteride drug evenly distributed in a spherical biodegradable polymer,
the microparticles have an average particle diameter of 20 to 70 μm,
the microparticles contain the biodegradable polymer and dutasteride at a weight ratio of 3:1 to 9:1,
the microparticles are capable of preventing an initial excessive release of dutasteride after injection into a body, and
the microparticles are capable of maintaining a drug administration effect of dutasteride according to an initial release after injection into the body.