	US 11,911,503 B2
	Manufacturing of semi-plastic pharmaceutical dosage units
Dominique Kluger, Klosterneuburg (AT); Albin Hauler, Traiskirchen (AT); Carsten Schmidt, Mainz (DE); David Schroeckenfuchs, Ernstbrunn (AT); and Niki Waldron, Vallejo, CA (US)
Assigned to Intervet Inc., Rahway, NJ (US)
Filed by Intervet Inc., Madison, NJ (US)
Filed on Apr. 8, 2021, as Appl. No. 17/225,634.
Application 17/225,634 is a continuation of application No. 16/515,762, filed on Jul. 18, 2019, granted, now 10,973,759.
Application 16/515,762 is a continuation of application No. 15/988,325, filed on May 24, 2018, abandoned.
Application 15/988,325 is a continuation of application No. 15/359,917, filed on Nov. 23, 2016, abandoned.
Application 15/359,917 is a continuation of application No. 14/082,813, filed on Nov. 18, 2013, granted, now 9,532,946, issued on Jan. 3, 2017.
Claims priority of provisional application 61/791,385, filed on Mar. 15, 2013.
Claims priority of provisional application 61/728,379, filed on Nov. 20, 2012.
Prior Publication US 2021/0236420 A1, Aug. 5, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/00 (2006.01); A61K 47/10 (2017.01); A61K 31/42 (2006.01); B29C 43/00 (2006.01); B29K 71/00 (2006.01); B29K 105/00 (2006.01); B29L 31/00 (2006.01)

CPC A61K 9/0056 (2013.01) [A61K 31/42 (2013.01); A61K 47/10 (2013.01); B29C 43/003 (2013.01); B29K 2071/02 (2013.01); B29K 2105/0035 (2013.01); B29L 2031/753 (2013.01)]

3 Claims

1. A soft chewable veterinary pharmaceutical product for oral administration,

wherein the soft chewable veterinary pharmaceutical product is obtainable by a process wherein the soft chewable veterinary pharmaceutical product is formed with a rotary moulding machine, comprising the steps of:

a) mixing at least one active pharmaceutical ingredient with one or more components wherein the components are dry components and liquid components to prepare a premix,

b) heating a polyethylene glycol forming agent until melting,

c) mixing the premix and the polyethylene glycol forming agent together to form a dough,

d) feeding the dough into a container connected with a rotary moulding machine; and

e) forming a soft chewable veterinary pharmaceutical product for oral administration in a rotary moulding machine,

wherein the liquid component comprises one or more oils and the polyethylene glycol forming agent is solid at room temperature and has a melting point between 45° C. and 100° C.;

wherein the temperature of the dough in step d) is between 35° C. and 45° C.; and

wherein the rotary moulding machine does not have a knockoff mechanism or a punch mechanism;

wherein the active pharmaceutical ingredient is 4-[5-(3,5-Dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl-N-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-benzamide; and

wherein the soft chewable veterinary pharmaceutical product has concave edges and has a weight of about 2 g or less or has a weight of more than about 10 g.