US 11,911,095 B2
Sequential mapping of cardiac arrhythmia without fiducial time reference
Mohammad Hassan Shariat, Kingston (CA); and Damian P. Redfearn, Kingston (CA)
Assigned to Queen's University at Kingston, Kingston (CA); and Kingston Health Sciences Centre, Kingston (CA)
Filed by Queen's University at Kingston, Kingston (CA); and Kingston Health Sciences Centre, Kingston (CA)
Filed on Sep. 25, 2020, as Appl. No. 17/032,996.
Claims priority of provisional application 62/907,072, filed on Sep. 27, 2019.
Prior Publication US 2021/0093217 A1, Apr. 1, 2021
Int. Cl. A61B 18/14 (2006.01); A61N 1/362 (2006.01); A61B 5/364 (2021.01); A61B 5/287 (2021.01); A61B 5/333 (2021.01); A61B 5/339 (2021.01); A61B 5/361 (2021.01); A61B 18/00 (2006.01)
CPC A61B 18/1492 (2013.01) [A61B 5/287 (2021.01); A61B 5/333 (2021.01); A61B 5/339 (2021.01); A61B 5/361 (2021.01); A61B 5/364 (2021.01); A61N 1/362 (2013.01); A61B 2018/00351 (2013.01); A61B 2018/00577 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for generating a map for cardiac wavefront propagation and for treating atrial arrhythmia, comprising:
obtaining a set of local activation times (LATs) of electrograms and location coordinates of electrodes of a catheter;
using a processor to execute code stored on non-transitory storage media compatible with the processor, the code containing instructions to direct the processor to generate an activation time function (ATF) by:
using two or more candidate functions (CFs) selected from a bank of CFs and estimating weighting and unknown parameters of the CFs to match available LATs of the electrodes;
determining the ATF as a combination of the selected CFs that matches the LATs;
using the ATF to generate at least one map selected from a propagation map, an isochronal map, and a conduction velocity map of the cardiac wavefront propagation; and
treating atrial arrhythmia in a subject by performing ablation therapy guided by the at least one map.