US 11,894,148 B2
Systems and methods for treating patients with diseases associated with viruses
Joseph P. Errico, Palm Beach Gardens, FL (US); Bruce J. Simon, Mountain Lakes, NJ (US); Peter Staats, Atlantic Beach, FL (US); and Thomas Errico, Coral Gables, FL (US)
Filed by ElectroCore, Inc., Rockaway, NJ (US)
Filed on Sep. 10, 2021, as Appl. No. 17/471,962.
Application 17/471,962 is a continuation in part of application No. 16/838,953, filed on Apr. 2, 2020.
Application 16/838,953 is a continuation in part of application No. 16/229,299, filed on Dec. 21, 2018, granted, now 11,581,090.
Claims priority of provisional application 62/609,807, filed on Dec. 22, 2017.
Prior Publication US 2022/0044828 A1, Feb. 10, 2022
Int. Cl. A61K 31/465 (2006.01); G16H 50/80 (2018.01); G16B 35/00 (2019.01); G16H 70/60 (2018.01); A61N 1/36 (2006.01)
CPC G16H 50/80 (2018.01) [A61N 1/36 (2013.01); A61N 1/36034 (2017.08); A61N 1/36053 (2013.01); G16B 35/00 (2019.02); G16H 70/60 (2018.01)] 11 Claims
OG exemplary drawing
 
1. A method of treating a medical disorder associated with a virus in the coronaviridae family in a patient, the method comprising:
positioning a contact surface of a device in contact with an outer skin surface of a neck of the patient;
applying, via the device, when the contact surface is in contact with the outer skin surface of the neck of the patient, an electrical impulse transcutaneously, via the contact surface, through the outer skin surface of the neck of the patient to a vagus nerve of the patient; and
wherein the electrical impulse is sufficient to reduce a level of C-reactive protein in a blood of the patient by at least 10 mg/L, wherein the medical disorder is a virus in the coronaviridae family, wherein each of the pulses has a frequency of about 1 kHz to about 20 kHz and an amplitude of about 2 to 12 volts; and
wherein the electrical impulse is applied to the patient according to a treatment paradigm based at least in part on an application of the electrical impulse as a single dose of about 30 seconds to about 5 minutes from 2 to 5 times per day.