US 11,892,435 B2
NMR methods for measuring pH in oral care, home care and personal care products
Chi-Yuan Cheng, Hillsborough, NJ (US); Zhigang Hao, Bridgewater, NJ (US); Long Pan, Somerset, NJ (US); and Zolijargal Balsandorj, Piscataway, NJ (US)
Assigned to Colgate-Palmolive Company, New York, NY (US)
Filed by Colgate-Palmolive Company, New York, NY (US)
Filed on Dec. 5, 2019, as Appl. No. 16/703,985.
Claims priority of provisional application 62/778,165, filed on Dec. 11, 2018.
Prior Publication US 2020/0182841 A1, Jun. 11, 2020
Int. Cl. G01N 33/15 (2006.01); G01N 24/08 (2006.01); G01N 31/22 (2006.01); G01R 33/465 (2006.01)
CPC G01N 31/221 (2013.01) [G01N 24/08 (2013.01); G01R 33/465 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method for determining pH of a composition, the method comprising:
preparing a calibration curve of a chemical species comprising an acid dissociation constant, wherein preparing the calibration curve comprises plotting a chemical shift of the chemical species relative to pH;
determining a chemical shift of a composition comprising the chemical species; and
determining the pH of the composition with the chemical shift of the composition and the calibration curve;
wherein the composition is a gel, paste, colloid, or aqueous solution and is selected from the group consisting of an oral care product, a home care product, a personal care product, and combinations thereof.