US 11,892,400 B1
Reflective depth interrogation for analyte measurement in liquids
Thomas G Campbell, Newbury Park, CA (US); and Jacob Y Wong, Goleta, CA (US)
Assigned to AIRWARE, INC, Newbury Park, CA (US)
Filed by Airware, Inc., Newbury Park, CA (US)
Filed on Aug. 25, 2023, as Appl. No. 18/238,300.
Application 18/238,300 is a continuation in part of application No. 18/114,414, filed on Feb. 27, 2023, granted, now 11,747,259.
Application 18/114,414 is a continuation in part of application No. 17/227,789, filed on Apr. 12, 2021, granted, now 11,604,138, issued on Mar. 14, 2023.
Application 17/227,789 is a continuation of application No. 17/073,297, filed on Oct. 17, 2020, granted, now 10,976,243, issued on Apr. 13, 2021.
Application 17/073,297 is a continuation in part of application No. 16/600,466, filed on Oct. 12, 2019, granted, now 10,983,046, issued on Apr. 20, 2021.
Application 16/600,466 is a continuation in part of application No. 16/359,350, filed on Mar. 20, 2019, granted, now 10,473,586, issued on Nov. 12, 2019.
Application 16/359,350 is a continuation in part of application No. 16/056,531, filed on Aug. 7, 2018, granted, now 10,241,044, issued on Mar. 26, 2019.
Application 16/056,531 is a continuation in part of application No. 15/785,829, filed on Oct. 17, 2017, granted, now 10,041,881, issued on Aug. 7, 2018.
Application 15/785,829 is a continuation in part of application No. 15/644,775, filed on Jul. 8, 2017, granted, now 9,823,185, issued on Nov. 21, 2017.
Application 15/644,775 is a continuation in part of application No. 15/594,418, filed on May 12, 2017, granted, now 9,726,601, issued on Aug. 8, 2017.
Application 15/594,418 is a continuation in part of application No. 15/444,136, filed on Feb. 27, 2017, granted, now 9,678,000, issued on Jun. 13, 2017.
Application 15/444,136 is a continuation in part of application No. 15/358,873, filed on Nov. 22, 2016, granted, now 9,606,053, issued on Mar. 28, 2017.
Int. Cl. G01N 33/487 (2006.01); G01N 21/31 (2006.01); G01N 21/35 (2014.01); A61B 5/145 (2006.01); A61B 5/00 (2006.01); G01N 21/3577 (2014.01); A61B 5/1455 (2006.01); G01N 21/21 (2006.01); G01N 33/49 (2006.01)
CPC G01N 21/3151 (2013.01) [A61B 5/0075 (2013.01); A61B 5/1451 (2013.01); A61B 5/1455 (2013.01); A61B 5/14532 (2013.01); G01N 21/3577 (2013.01); G01N 33/487 (2013.01); A61B 5/0062 (2013.01); A61B 2562/0238 (2013.01); G01N 21/21 (2013.01); G01N 33/49 (2013.01); G01N 2021/3148 (2013.01); G01N 2201/10 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A process for quantifying a concentration of a targeted molecule in a liquid sample through use of an absorption spectroscopy process, comprising:
(1) pulsing a signal beam with a signal pulsed source;
(2) pulsing a reference beam with a reference pulsed source;
(3) spatially combining the pulsed signal beam and the pulsed reference beam into a single radiation beam which passes into the liquid sample to a first effective depth and then is reflected out of the liquid sample;
(4) detecting a pulsed signal beam output and a pulsed reference beam output after the single radiation beam passes out of the liquid sample;
(5) processing the pulsed signal beam output and the pulsed reference beam output to obtain a value over a preselected period of time;
(6) repeating steps (1) through (5) for at least one additional effective depth to obtain a sampling dataset; and
(7) calculating a concentration level of the targeted particle in the liquid sample based on the sampling dataset;
wherein the signal pulsed source emits radiation at the signal bandwidth which is coincident with an absorption band of the targeted particle while the reference pulsed source emits radiation at a reference wavelength which is not coincident with the absorption band; and
wherein the signal pulsed source is separate from the reference pulsed source.