US 11,892,397 B2
Endotoxin testing assay and method of same
Jing Yong Ye, San Antonio, TX (US); and Jonathan D. Scudder, San Antonio, TX (US)
Assigned to Board of Regents, The University of Texas System, Austin, TX (US)
Filed by BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed on May 10, 2021, as Appl. No. 17/316,467.
Application 17/316,467 is a continuation in part of application No. 16/162,261, filed on Oct. 16, 2018, granted, now 11,099,189.
Claims priority of provisional application 62/573,535, filed on Oct. 17, 2017.
Prior Publication US 2021/0262924 A1, Aug. 26, 2021
Int. Cl. G01N 21/31 (2006.01)
CPC G01N 21/31 (2013.01) [G01N 2201/0633 (2013.01); G01N 2201/0636 (2013.01); G01N 2201/0638 (2013.01); G01N 2201/06113 (2013.01); G01N 2201/08 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A Limulus Amoebocyte Lysate (LAL) endotoxin assay system comprising an open cavity photonic crystal total internal reflection (PC-TIR) biosensor, the PC-TIR biosensor further comprising a prism, a substrate, at least one dielectric layer on the substrate, at least one analyte well on the at least one dielectric layer, the substrate being coupled to the prism, the endotoxin assay system configured to detect endotoxin in an analyte in the at least one analyte well by monitoring changes in a refractive index of the analyte.