US 11,891,510 B2
Poloxamer compositions and methods of making and using same
Scott Wilson, Lenexa, KS (US); Kevin Kent, St. Louis, MO (US); and Chandana Sharma, Lenexa, KS (US)
Assigned to Sigma-Aldrich Co. LLC, St. Louis, MO (US)
Appl. No. 16/645,915
Filed by Sigma-Aldrich Co. LLC, St. Louis, MO (US)
PCT Filed Dec. 6, 2018, PCT No. PCT/US2018/064350
§ 371(c)(1), (2) Date Mar. 10, 2020,
PCT Pub. No. WO2019/125783, PCT Pub. Date Jun. 27, 2019.
Claims priority of provisional application 62/608,826, filed on Dec. 21, 2017.
Prior Publication US 2021/0347987 A1, Nov. 11, 2021
Int. Cl. C08L 71/02 (2006.01); C08L 71/00 (2006.01); C12N 5/00 (2006.01)
CPC C08L 71/02 (2013.01) [C08L 71/00 (2013.01); C12N 5/0043 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A culture medium for in vitro culture of cells, the medium comprising a poloxamer composition derived from poloxamer 188 and having the formula I:

OG Complex Work Unit Chemistry
wherein x, y, and z are positive integers such that the composition has an average molecular weight in the range of about 6,000 g/mol to about 7,600 g/mol.