US 11,891,482 B2
Polymer excipients for drug delivery applications
Kevin N. Sill, Tampa, FL (US); and Bradford T. Sullivan, Clearwater, FL (US)
Assigned to TYNDALL FORMULATION SERVICES, LLC, Tampa, FL (US)
Filed by TYNDALL FORMULATION SERVICES, LLC, Tampa, FL (US)
Filed on Feb. 15, 2022, as Appl. No. 17/672,341.
Application 17/672,341 is a division of application No. 16/740,195, filed on Jan. 10, 2020, granted, now 11,286,344.
Prior Publication US 2022/0251296 A1, Aug. 11, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/19 (2006.01); A61K 9/16 (2006.01); A61K 31/4738 (2006.01); A61K 31/337 (2006.01); C08G 69/10 (2006.01)
CPC C08G 69/10 (2013.01) [A61K 9/1641 (2013.01); A61K 9/19 (2013.01); A61K 31/337 (2013.01); A61K 31/4738 (2013.01)] 18 Claims
 
1. A method of increasing the solubility of a hydrophobic molecule in an aqueous solution comprising encapsulating the hydrophobic molecule in a multiblock copolymer of Formula I:

OG Complex Work Unit Chemistry
wherein:
R1a is H or an optionally substituted aliphatic group;
R1b is H or an optionally substituted aliphatic group;
R2 is H, an optionally substituted aliphatic group or an optionally substituted CO—(C1-C6) aliphatic group;
each Ry is independently the side chain of γ-benzyl-D-glutamate, D-leucine, D-tyrosine, D-phenylalanine, D-alanine, D-valine, D-isoleucine, D-norleucine, O-acetyl-D-tyrosine, O-benzyl-D-tyrosine, or ε-benzyl-D-lysine;
each Rz is independently the side chain of γ-benzyl-L-glutamate, L-leucine, L-tyrosine, L-phenylalanine, L-alanine, L-valine, L-isoleucine, L-norleucine, O-acetyl-L-tyrosine, O-benzyl-L-tyrosine, or ε-benzyl-L-lysine;
x is 125-350;
y is 5-35;
z is 5-35.