CPC C08G 69/10 (2013.01) [A61K 9/1641 (2013.01); A61K 9/19 (2013.01); A61K 31/337 (2013.01); A61K 31/4738 (2013.01)] | 18 Claims |
1. A method of increasing the solubility of a hydrophobic molecule in an aqueous solution comprising encapsulating the hydrophobic molecule in a multiblock copolymer of Formula I:
wherein:
R1a is H or an optionally substituted aliphatic group;
R1b is H or an optionally substituted aliphatic group;
R2 is H, an optionally substituted aliphatic group or an optionally substituted CO—(C1-C6) aliphatic group;
each Ry is independently the side chain of γ-benzyl-D-glutamate, D-leucine, D-tyrosine, D-phenylalanine, D-alanine, D-valine, D-isoleucine, D-norleucine, O-acetyl-D-tyrosine, O-benzyl-D-tyrosine, or ε-benzyl-D-lysine;
each Rz is independently the side chain of γ-benzyl-L-glutamate, L-leucine, L-tyrosine, L-phenylalanine, L-alanine, L-valine, L-isoleucine, L-norleucine, O-acetyl-L-tyrosine, O-benzyl-L-tyrosine, or ε-benzyl-L-lysine;
x is 125-350;
y is 5-35;
z is 5-35.
|