CPC C07K 7/64 (2013.01) [C07H 21/04 (2013.01); C07K 1/113 (2013.01); C07K 5/0812 (2013.01); C07K 5/1013 (2013.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C07K 11/00 (2013.01); C07K 11/02 (2013.01); C07K 19/00 (2013.01); C12P 21/02 (2013.01); A61K 38/00 (2013.01)] | 14 Claims |
1. A peptide compound having a cyclic portion, wherein:
(i) the peptide compound contains a cyclic portion composed of 5 to 12 amino acids and amino acid analog residues in total, and has 9 to 13 amino acids and amino acid analogs in total,
(ii) the peptide compound contains at least three N-alkylated amino acids, wherein the N-alkylated amino acids are N-methylated amino acids,
(iii) the peptide compound has a ClogP value of 8 to 15, and
(iv) the peptide compound has at least one amide bond formed between a side chain of an amino acid or an amino acid analog and a nitrogen atom of the main chain of another amino acid or amino acid analog,
wherein the peptide compound comprises an amide bond formed between a side chain of an optionally substituted glutamic acid or an optionally substituted aspartic acid and a nitrogen atom of the main chain of another amino acid.
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