US 11,891,442 B2
Compositions and methods for treating age-related diseases
Anton Wyss-Coray, Palo Alto, CA (US); John Vincent Pluvinage, Atherton, CA (US); Michael C. Bassik, Stanford, CA (US); Michael Haney, Stanford, CA (US); Benjamin Smith, Stanford, CA (US); and Carolyn Bertozzi, Stanford, CA (US)
Assigned to THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, Stanford, CA (US); and THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, Washington, DC (US)
Appl. No. 16/956,339
Filed by THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, Stanford, CA (US); and THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, Washington, DC (US)
PCT Filed Dec. 21, 2018, PCT No. PCT/US2018/067250
§ 371(c)(1), (2) Date Jun. 19, 2020,
PCT Pub. No. WO2019/126725, PCT Pub. Date Jun. 27, 2019.
Claims priority of provisional application 62/672,420, filed on May 16, 2018.
Claims priority of provisional application 62/609,961, filed on Dec. 22, 2017.
Prior Publication US 2020/0317778 A1, Oct. 8, 2020
Int. Cl. C07K 16/28 (2006.01); A61P 25/28 (2006.01); A61K 39/395 (2006.01); A61K 39/00 (2006.01); A61K 38/47 (2006.01); C12N 9/24 (2006.01); A61K 47/68 (2017.01); A61M 25/00 (2006.01)
CPC C07K 16/2803 (2013.01) [A61K 38/47 (2013.01); A61K 39/001113 (2018.08); A61K 39/3955 (2013.01); A61K 47/6815 (2017.08); A61K 47/6849 (2017.08); A61P 25/28 (2018.01); C12N 9/2402 (2013.01); C12Y 302/01018 (2013.01); A61K 2039/505 (2013.01); A61M 25/0097 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A method of treating a neurodegenerative disease comprising: exposing one or more of a subject's microglia, macrophage and/or other phagocytic cells to an anti-CD22 antibody wherein said exposing treats said neurodegenerative disease wherein said neurodegenerative disease is Niemann-Pick disease Type C (NPC).