	US 11,891,440 B2
	Antibodies with improved stability to intestinal digestion, polynucleotides thereof and methods of use thereof to treat disease
Randall Edward Burton, Billerica, MA (US)
Assigned to CIRCLE33 LLC, Jackson, WY (US)
Appl. No. 15/765,958
Filed by Circle33 LLC, Jackson, WY (US)
PCT Filed Sep. 29, 2016, PCT No. PCT/US2016/054304 § 371(c)(1), (2) Date Sep. 24, 2020, PCT Pub. No. WO2017/062253, PCT Pub. Date Apr. 13, 2017.
Claims priority of provisional application 62/237,270, filed on Oct. 5, 2015.
Prior Publication US 2022/0073602 A1, Mar. 10, 2022
Int. Cl. A61K 9/00 (2006.01); A61K 39/00 (2006.01); C07K 16/24 (2006.01); A61P 1/04 (2006.01)

CPC C07K 16/241 (2013.01) [A61K 9/0053 (2013.01); A61P 1/04 (2018.01); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); C07K 2317/20 (2013.01); C07K 2317/21 (2013.01); C07K 2317/522 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/53 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/94 (2013.01)]

20 Claims

1. An isolated recombinant monoclonal antibody comprising (a) heavy and light chain CDRs from a non-bovine antibody and (b) a constant region comprising all or a portion of a bovine IgG1 constant region, wherein the constant region or portion thereof comprises all or a portion of a bovine IgG1 hinge region, said all or a portion of the bovine IgG1 hinge region comprising a cluster of three disulfide bonds linking the hinge regions of two heavy chains together, and/or a hinge region amino acid sequence that is less susceptible to common proteases.