	US 11,891,436 B2
	Monoclonal antibodies to growth and differentiation factor 15 (GDF-15)
Jörg Wischhusen, Würzburg (DE); Markus Junker, Würzburg (DE); Thomas Müller, Veitshöchheim (DE); and Stefan Saremba, Würzburg (DE)
Assigned to JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG, Würzburg (DE)
Filed by JULIUS-MAXIMILLIANS-UNIVERSITÄT WÜRZBURG, Würzburg (DE)
Filed on Aug. 11, 2020, as Appl. No. 16/990,929.
Application 16/990,929 is a continuation of application No. 15/918,841, filed on Mar. 12, 2018, granted, now 10,781,251.
Application 15/918,841 is a continuation of application No. 14/431,281, abandoned, previously published as PCT/EP2013/070127, filed on Sep. 26, 2013.
Claims priority of application No. 12186185 (EP), filed on Sep. 26, 2012.
Prior Publication US 2021/0054060 A1, Feb. 25, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/395 (2006.01); C07K 16/22 (2006.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01)

CPC C07K 16/22 (2013.01) [A61K 45/06 (2013.01); A61K 39/3955 (2013.01); A61K 2039/505 (2013.01); C07K 2317/34 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)]

13 Claims

1. A method of antagonizing human GDF-15, the method comprising:

contacting human GDF-15 with an antibody, or an antigen-binding portion thereof, that specifically binds to human GDF-15, wherein the antibody or antigen-binding portion thereof comprises: a heavy chain variable domain comprising the heavy chain CDR1, CDR2 and CDR3 amino acid sequences of antibody B1-23; and a light chain variable domain comprising the light chain CDR1, CDR2 and CDR3 amino acid sequences of antibody B1-23.