US 11,891,423 B2
Fusion protein binding to CD47 protein and application thereof
Ming Lv, Zhejiang (CN); Xiaoran Ding, Zhejiang (CN); Shiwei Miao, Zhejiang (CN); Bin Tan, Zhejiang (CN); and Xuegong Wang, Zhejiang (CN)
Assigned to HANGZHOU SUMGEN BIOTECH CO., LTD., Zhejiang (CN); and SUMGEN MAB (BEIJING) BIOTECH CO., LTD., Beijing (CN)
Appl. No. 17/048,202
Filed by HANGZHOU SUMGEN BIOTECH CO., LTD., Zhejiang (CN); and SUMGEN MAB (BEIJING) BIOTECH CO., LTD., Beijing (CN)
PCT Filed Apr. 16, 2019, PCT No. PCT/CN2019/082863
§ 371(c)(1), (2) Date Oct. 16, 2020,
PCT Pub. No. WO2019/201236, PCT Pub. Date Oct. 24, 2019.
Claims priority of application No. 201810343482.9 (CN), filed on Apr. 17, 2018.
Prior Publication US 2021/0171593 A1, Jun. 10, 2021
Int. Cl. C07K 16/46 (2006.01); C07K 19/00 (2006.01); C07K 14/00 (2006.01); A61K 39/395 (2006.01); C07K 14/47 (2006.01); A61P 35/00 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01)
CPC C07K 14/4703 (2013.01) [A61P 35/00 (2018.01); A61K 38/00 (2013.01); A61K 39/395 (2013.01); A61K 2039/505 (2013.01); C07K 16/46 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01)] 9 Claims
 
1. A human SIRPα (signal regulatory protein α) domain mutant, wherein the human SIRPα domain mutant comprises an amino acid sequence as set forth in any one of SEQ ID NOs: 2, 3, 10, 11, 12 and 14.