US 11,891,409 B2
Trifluoromethyl alkenylphosphonate and preparation method therefor
Jianping Zou, Suzhou (CN); Chengkun Li, Suzhou (CN); Dongliang Zhang, Suzhou (CN); Zekun Tao, Suzhou (CN); and Jianan Li, Suzhou (CN)
Assigned to SOOCHOW UNIVERSITY, Suzhou (CN)
Filed by SOOCHOW UNIVERSITY, Suzhou (CN)
Filed on Apr. 9, 2021, as Appl. No. 17/226,213.
Application 17/226,213 is a continuation of application No. PCT/CN2018/109541, filed on Oct. 9, 2018.
Prior Publication US 2021/0221831 A1, Jul. 22, 2021
Int. Cl. C07F 9/40 (2006.01)
CPC C07F 9/40 (2013.01) 6 Claims
 
1. A method for preparing a trifluoromethyl alkenylphosphonate derivative comprising:
reacting an acetylene derivative, an iodine compound, and a phosphorus reagent in a solvent at room temperature to obtain the trifluoromethyl alkenylphosphonate derivative,
wherein:
the acetylene derivative has the following structure:

OG Complex Work Unit Chemistry
the iodine compound has the following structure:

OG Complex Work Unit Chemistry
the phosphorus reagent has the following structure:
P(OR4)3;
the trifluoromethyl alkenylphosphonate derivative has the following structure:

OG Complex Work Unit Chemistry
R1 is aryl, cyano, or ester; R2 is hydrogen, cyano or ester; and R4 is methyl, ethyl, isopropyl or butyl.