CPC C07D 495/04 (2013.01) [A61K 38/1709 (2013.01); C07C 235/20 (2013.01); C07C 317/08 (2013.01); C07D 207/14 (2013.01); C07D 211/58 (2013.01); C07D 211/62 (2013.01); C07D 231/40 (2013.01); C07D 295/185 (2013.01); C07D 295/26 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 409/04 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01); C12N 9/14 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); C12Y 306/05002 (2013.01); G01N 2500/04 (2013.01)] | 27 Claims |
1. A human K-Ras protein having a cysteine at residue 12, wherein said cysteine is covalently bonded to a compound, wherein said compound has the formula
R1-L1-L2-L3-E,
wherein
R1 is substituted or unsubstituted fused ring aryl or substituted or unsubstituted fused ring heteroaryl;
L1 is a substituted or unsubstituted heteroarylene;
L2 is a bond;
L3 is a substituted or unsubstituted spirocyclic linker; and, prior to covalently bonding to the cysteine 12,
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