US 11,891,392 B2
Pharmacophore for trail induction
Kim D. Janda, La Jolla, CA (US); Nicholas T. Jacob, San Diego, CA (US); and Jonathan W. Lockner, San Diego, CA (US)
Assigned to The Scripps Research Institute, La Jolla, CA (US)
Filed by THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US)
Filed on Jul. 12, 2021, as Appl. No. 17/372,894.
Application 17/372,894 is a continuation of application No. 16/848,032, filed on Apr. 14, 2020, abandoned.
Application 16/848,032 is a continuation of application No. 16/359,633, filed on Mar. 20, 2019, granted, now 10,633,385, issued on Apr. 28, 2020.
Application 16/359,633 is a continuation of application No. 15/126,192, granted, now 10,239,877, issued on Mar. 26, 2019, previously published as PCT/US2015/023362, filed on Mar. 30, 2015.
Claims priority of provisional application 61/972,689, filed on Mar. 31, 2014.
Prior Publication US 2022/0002300 A1, Jan. 6, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 471/14 (2006.01); A61K 31/519 (2006.01)
CPC C07D 471/14 (2013.01) [A61K 31/519 (2013.01)] 5 Claims
 
1. A method for making a compound 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9,-hexahydroimidazo[1,2-α]pyrido[3,4-e]pyrimidin-5(4H)-one

OG Complex Work Unit Chemistry
comprising the step of mixing N-(2-methylbenzyl)-4,5-dihydro-1H-imidazol-2-amine with methyl 1-benzyl-4-oxopiperidine-3-carboxylate to afford the compound.