CPC C07D 295/073 (2013.01) [C07D 211/18 (2013.01); C07D 211/26 (2013.01); C07D 211/46 (2013.01); C07D 211/54 (2013.01); C07D 211/58 (2013.01); C07D 295/195 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 405/14 (2013.01); C07D 407/02 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01); C07D 471/08 (2013.01)] | 5 Claims |
1. A method of treating a disease or condition, wherein the disease or condition is selected from hypocholesterolemia, coronary disease, hypertension, hypercholesterolemia, atherosclerosis, and diabetes, the method comprising administering to a patient in need thereof a compound of Formula (I):
or a pharmaceutically acceptable salt thereof;
wherein:
m is 0, 1, or 2;
X1 is N;
X2, X3, and X4 are each independently CR2 or CR2R2;
ring B is a six-membered ring comprising one or more double bonds;
X5 and X6 are CR2;
X7 is C;
ring A is:
where the wavy line in ring A indicates the point of attachment to
L is a bond;
R1 in each instance is independently halo or C1-6 alkyl optionally substituted with halo or hydroxy;
R2 in each instance is independently hydrogen, halo, or C1-6 alkyl optionally substituted with halo or hydroxy
R3 is halo, C1-6 alkyl, C3-6 cycloalkyl, or aryl;
wherein each C1-6 alkyl, C3-6 cycloalkyl, or aryl of R3 is optionally substituted with 1 to 3 substituents independently selected from halo and hydroxy; and
R4 is hydrogen or C1-6 alkyl;
provided that when A is attached via a carbon atom to the remainder of the molecule and m is other than 0, then R1 is not appended to the same carbon atom.
|