US 11,891,367 B2
Method for preparing 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide
Michel Feraud, Marseilles (FR); Babak Sayah, Marseilles (FR); Stéphane Queru, Marseilles (FR); and Marina Laurent, Marseilles (FR)
Assigned to PROVEPHARM LIFE SOLUTIONS, Marseilles (FR)
Filed by PROVEPHARM LIFE SOLUTIONS, Marseilles (FR)
Filed on Jun. 29, 2021, as Appl. No. 17/362,283.
Application 17/362,283 is a continuation of application No. 16/490,480, granted, now 11,078,169, previously published as PCT/FR2018/050372, filed on Feb. 16, 2018.
Claims priority of application No. 1751700 (FR), filed on Mar. 2, 2017.
Prior Publication US 2021/0323937 A1, Oct. 21, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 285/15 (2006.01)
CPC C07D 285/15 (2013.01) 19 Claims
 
1. A one-pot process for preparing 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide, the process using phenothiazine as a starting product and comprising the following steps:
a) treating phenothiazine with diiodine, and
b) treating the reaction medium directly resulting from step a) with dimethylamine,
wherein, in step b), the dimethylamine is introduced into the reaction medium in the form of a solution in water, or a mixture of water with one or more of methanol, ethanol, or tetrahydrofuran.