	US 11,891,364 B2
	Methods of selectively forming substituted pyrazines
Michael Francis Dube, Winston-Salem, NC (US); and William Monroe Coleman, III, Conway, SC (US)
Assigned to R.J. Reynolds Tobacco Company, Winston-Salem, NC (US)
Filed by R.J. Reynolds Tobacco Company, Winston-Salem, NC (US)
Filed on Jul. 8, 2021, as Appl. No. 17/370,643.
Application 17/370,643 is a division of application No. 15/468,665, filed on Mar. 24, 2017, granted, now 11,091,446.
Prior Publication US 2021/0403437 A1, Dec. 30, 2021
Int. Cl. C07D 241/10 (2006.01); C07D 241/12 (2006.01); C07D 241/36 (2006.01); A24B 15/38 (2006.01); A24B 15/42 (2006.01); A24B 13/00 (2006.01); A24D 1/02 (2006.01); C07C 49/17 (2006.01); C07H 3/02 (2006.01)

CPC C07D 241/12 (2013.01) [A24B 13/00 (2013.01); A24B 15/38 (2013.01); A24D 1/02 (2013.01)]

20 Claims

1. A method of forming pyrazines comprising:

receiving a carbon source solution comprising at least one sugar and at least one buffer;

mixing the carbon source solution with at least one nitrogen source to form a reaction solution; and

heating the reaction solution to a reaction temperature and holding the reaction solution at the reaction temperature for a time sufficient to produce a reaction product comprising at least one substituted pyrazine.