US 11,890,439 B2
Drug delivery device with intravesical tolerability
Michael J. Cima, Winchester, MA (US); and Heejin Lee, Bedford, MA (US)
Assigned to TARIS Biomedical LLC, Lexington, MA (US)
Filed by TARIS Biomedical LLC, Lexington, MA (US)
Filed on May 4, 2021, as Appl. No. 17/307,082.
Application 17/307,082 is a continuation of application No. 14/224,256, filed on Mar. 25, 2014, granted, now 11,065,426.
Application 14/224,256 is a continuation of application No. 12/972,364, filed on Dec. 17, 2010, granted, now 8,679,094, issued on Mar. 25, 2014.
Claims priority of provisional application 61/325,713, filed on Apr. 19, 2010.
Claims priority of provisional application 61/287,649, filed on Dec. 17, 2009.
Prior Publication US 2021/0252262 A1, Aug. 19, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 31/00 (2006.01); A61K 31/167 (2006.01); A61K 9/00 (2006.01); A61L 31/18 (2006.01); A61K 9/20 (2006.01); A61K 31/00 (2006.01); A61L 31/16 (2006.01); A61F 2/04 (2013.01)
CPC A61M 31/002 (2013.01) [A61K 9/0034 (2013.01); A61K 9/2072 (2013.01); A61K 31/00 (2013.01); A61K 31/167 (2013.01); A61L 31/16 (2013.01); A61L 31/18 (2013.01); A61M 31/00 (2013.01); A61F 2/042 (2013.01); A61L 2300/402 (2013.01); A61L 2300/602 (2013.01); A61L 2430/22 (2013.01)] 29 Claims
OG exemplary drawing
 
1. An intravesical drug delivery device, comprising:
an elongated elastic body comprising a drug reservoir lumen defined therein; and
a drug formulation disposed within the drug reservoir lumen, the drug formulation comprising a drug which comprises a kinase inhibitor,
wherein the elongated elastic body has a coiled retention shape having (i) dimensions that provide intravesical mobility and prevent voiding of the device through the urethra, and (ii) a maximum dimension in any direction of 6 cm or less when in an uncompressed state, and
wherein the device exerts a maximum acting force less than 1 N when the device is compressed from the retention shape to a shape having a maximum dimension in any direction of 3 cm or less.